منابع مشابه
Nanos and pumilio establish embryonic polarity in Drosophila by promoting posterior deadenylation of hunchback mRNA.
Nanos protein promotes abdominal structures in Drosophila embryos by repressing the translation of maternal hunchback mRNA in the posterior. To study the mechanism of nanos-mediated translational repression, we first examined the mechanism by which maternal hunchback mRNA is translationally activated. In the absence of nanos activity, the poly(A) tail of hunchback mRNA is elongated concomitant ...
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Apical-basal polarity plays critical roles in the functions of epithelial tissues. However, the mechanisms of epithelial polarity establishment and maintenance remain to be fully elucidated. Here we show that the membrane-associated guanylate kinase (MAGUK) family protein Dlg5 is required for the maintenance of apical polarity of follicle epithelium during Drosophila oogenesis. Dlg5 localizes a...
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Mathematical chemistry is a branch of theoretical chemistry for discussion and prediction of the molecular structure using mathematical methods without necessarily referring to quantum mechanics. In theoretical chemistry, distance-based molecular structure descriptors are used for modeling physical, pharmacologic, biological and other properties of chemical compounds. The Wiener Polarity index ...
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Research Roundup Research Roundup for example, two nearby cells can somehow tell which one is closer to the equator (middle) of the eye, and specify the R3 (equatorial) and R4 (polar) fates, accordingly. " This is one of the great puzzles of PCP, " says Simon. " The cells are reading the gradient rather than the absolute values, and sensing the smallest differences. " For that process to have a...
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ژورنال
عنوان ژورنال: Nature Reviews Neuroscience
سال: 2015
ISSN: 1471-003X,1471-0048
DOI: 10.1038/nrn3960